IGF-I; IGF-binding protein-3 and breast cancer risk
نویسندگان
چکیده
منابع مشابه
Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on.
Insulin-like growth factor (IGF)-I, and its main binding protein, IGFBP-3, are multi-functional regulatory peptides of cell growth and survival, attributes important for tumourigenesis. Following seminal work published in 1998, it has been hypothesised that circulating concentrations of these growth factors may be associated with cancer risk. Systematic reviews have reported that high normal ra...
متن کاملInsulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer.
Epidemiological evidence supports a role for the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the induction and progression of various cancers. Estrogen, which plays a role in the etiology of breast cancer, both regulates and is influenced by the IGF family. Risk of breast cancer associated with serum levels of IGF-I and/or IGFBPs may therefore depend upon menopausa...
متن کاملNo association between serum insulin-like growth factor (IGF)-I, IGF-binding protein-3, and lung cancer risk.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland; Information Management Services, Inc., Silver Spring, Maryland; Departments of Medicine and Oncology, Lady Davis Research Institute of the Jewish General Hospital and McGill University, Montreal, Quebec, Canada; and Department of Health Promotion and Chronic Disease Prevention, National Publi...
متن کاملInsulin-like growth factor I (IGF-I) and IGF-binding protein-3 in benign prostatic hyperplasia and prostate cancer.
In view of evidence indicating significant involvement of the insulin-like growth factor (IGF) system in the pathogenesis of prostate cancer, we measured serum IGF-I and IGF-binding protein-3 (IGFBP-3) in men with benign prostatic hyperplasia (BPH; n = 75) or prostatic carcinoma (CaP; n = 84). The age-matched patient populations were selected to have circulating prostate-specific antigen (PSA),...
متن کاملRe: Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.
A recent study (1) suggested that elevated plasma levels of insulin-like growth factor-I (IGF-I) were a predictor of advanced-stage prostate cancer. We have studied IGF-I in prostate cancer and have found no relationship to disease stage. We studied IGF-I in a group of 126 men with prostate cancer and benign prostatic hypertrophy (BPH). Participants in our study were found through urology and r...
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ژورنال
عنوان ژورنال: Breast Cancer Online
سال: 2005
ISSN: 1470-9031
DOI: 10.1017/s1470903104003001